BIOLOGICAL EVALUATION OF ANTIANDROGENIC EFFECT OF SOME PLANTS
KAREM EL-SAYED ALY FOUDA;
Abstract
Androgen-related diseases impair the well-being of many aging
men. Unfortunately, the medications used to treat these diseases have
many side effects. Therefore, there is a significant need for the
development of novel drugs to treat androgen-related diseases. So the
present study was designed to study the anti-androgenic effect of some
plants. Since some plants (flaxseeds, sesame seeds, safflower seeds and
soybean seeds) were analyzed then petroleum ether and ethanol
extracts were prepared from these samples. Some phytochemicals such
as total phenolic compounds content, fatty acids, hydrocarbons and
phytosterols contents were determined in all the studied plants. Also
the anti-cancer effect of all the plants powder under investigation were
studied against prostate cancer using cell-line technique. In the first
experiment of the present study flaxseeds, sesame seeds, safflower
seeds and soybean seeds were evaluated as anti-androgenic agents in
form of petroleum ether, ethanol extracts and whole powder using
castrated rats. Since eighty four male rats were divided into 14 groups.
Group one was served as normal health control. Group two was served
as castrated/testosterone control. The other 12 groups
(castrated/testosterone) were served as tested groups. Excluding the
normal control group, all animals were castrated. Starting one day after
surgery, the rats were injected subcutaneously for ten days with
testosterone propionate (0.15 μg/kg rat body weight). Groups 3 and 4
were fed on balanced diet and given daily oral dose of flaxseeds
petroleum or ethanol extract (300mg/kg rat body weight). Group 5 was
fed on balanced diet containing 20% of flaxseeds powder. Groups 6
men. Unfortunately, the medications used to treat these diseases have
many side effects. Therefore, there is a significant need for the
development of novel drugs to treat androgen-related diseases. So the
present study was designed to study the anti-androgenic effect of some
plants. Since some plants (flaxseeds, sesame seeds, safflower seeds and
soybean seeds) were analyzed then petroleum ether and ethanol
extracts were prepared from these samples. Some phytochemicals such
as total phenolic compounds content, fatty acids, hydrocarbons and
phytosterols contents were determined in all the studied plants. Also
the anti-cancer effect of all the plants powder under investigation were
studied against prostate cancer using cell-line technique. In the first
experiment of the present study flaxseeds, sesame seeds, safflower
seeds and soybean seeds were evaluated as anti-androgenic agents in
form of petroleum ether, ethanol extracts and whole powder using
castrated rats. Since eighty four male rats were divided into 14 groups.
Group one was served as normal health control. Group two was served
as castrated/testosterone control. The other 12 groups
(castrated/testosterone) were served as tested groups. Excluding the
normal control group, all animals were castrated. Starting one day after
surgery, the rats were injected subcutaneously for ten days with
testosterone propionate (0.15 μg/kg rat body weight). Groups 3 and 4
were fed on balanced diet and given daily oral dose of flaxseeds
petroleum or ethanol extract (300mg/kg rat body weight). Group 5 was
fed on balanced diet containing 20% of flaxseeds powder. Groups 6
Other data
| Title | BIOLOGICAL EVALUATION OF ANTIANDROGENIC EFFECT OF SOME PLANTS | Authors | KAREM EL-SAYED ALY FOUDA | Issue Date | 2015 |
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