Screening for Immunoglobulin Deficiency in Egyptian Children with Repeated Infections
Noha Shafiq Al-Eitewy;
Abstract
The aim of the current study was to screen for immunoglobulin deficiency among Egyptian infants and children presenting with recurrent, severe and/ or unusual infections.
This study involved 75 infants and children who were presenting to the hospital with recurrent, severe and/or unusual infection or fulfilling 2 or more of the 10 warning signs of primary immunodeficiency disorders. Subjects were enrolled from the outpatient and inpatient sections, emergency department and intensive care units after consideration of inclusion and exclusion criteria. Patients with known cause of secondary immunodeficiency as tuberculosis, nephrotic syndrome, or protein losing enteropathy or those having known anatomical or functional defects that predispose to infections and who receiving immunosuppressive drugs were excluded from the study.
Besides full history taking and detailed clinical examination, the following laboratory investigations were performed: CBC with manual differential count and quantitative measurement of serum immunoglobulins (Ig A, Ig M, Ig G, and Ig E).
They were 52 boys (69.3%), 23 girls (30.7%) with age ranged from six months to fourteen years with mean age 2.73± 2.88 years.
According to infection profile of studied patients, 48 patients (64.0%) presented before the age of 6 months, while
This study involved 75 infants and children who were presenting to the hospital with recurrent, severe and/or unusual infection or fulfilling 2 or more of the 10 warning signs of primary immunodeficiency disorders. Subjects were enrolled from the outpatient and inpatient sections, emergency department and intensive care units after consideration of inclusion and exclusion criteria. Patients with known cause of secondary immunodeficiency as tuberculosis, nephrotic syndrome, or protein losing enteropathy or those having known anatomical or functional defects that predispose to infections and who receiving immunosuppressive drugs were excluded from the study.
Besides full history taking and detailed clinical examination, the following laboratory investigations were performed: CBC with manual differential count and quantitative measurement of serum immunoglobulins (Ig A, Ig M, Ig G, and Ig E).
They were 52 boys (69.3%), 23 girls (30.7%) with age ranged from six months to fourteen years with mean age 2.73± 2.88 years.
According to infection profile of studied patients, 48 patients (64.0%) presented before the age of 6 months, while
Other data
| Title | Screening for Immunoglobulin Deficiency in Egyptian Children with Repeated Infections | Other Titles | استكشاف نقص الأجسام المناعية فى الأطفال المصريين المصابين بالالتهابات الميكروبية المتكررة | Authors | Noha Shafiq Al-Eitewy | Issue Date | 2019 |
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