Effect of Vitamin D Supplementation on Doxorubicin-Induced Cardiotoxicity in Rats
Yasmin Mohammed Khaled Amin;
Abstract
The present study was planned to investigate the potential protective role of vitamin D on the cardiac dysfunction induced by chronic doxorubicin exposure, and to throw more light on the possible underlying mechanism (s) for such effect.
The study was performed on 70 female albino rats which were divided into 4 groups:
Group 1: Control group (Control) (n=21):
Rats in this group received six doses of intraperitoneal (i.p) saline injections twice weekly for 3 weeks and 0.1 ml distilled water by gavage 5 days a week, for 3 weeks.
Group 2: Doxorubicin-treated group (Dox) (n=18):
Rats in this group received six doses of intraperitoneal injection (i.p) of doxorubicin in a dose of 2.5 mg/kg body weight twice weekly for 3 weeks (cumulative dose: 15 mg/kg) (Akolkar et al., 2017) and 0.1 ml distilled water by gavage 5 days a week for 3 weeks.
Group 3: Vitamin D-supplemented group (Vit D) (n=16):
The study was performed on 70 female albino rats which were divided into 4 groups:
Group 1: Control group (Control) (n=21):
Rats in this group received six doses of intraperitoneal (i.p) saline injections twice weekly for 3 weeks and 0.1 ml distilled water by gavage 5 days a week, for 3 weeks.
Group 2: Doxorubicin-treated group (Dox) (n=18):
Rats in this group received six doses of intraperitoneal injection (i.p) of doxorubicin in a dose of 2.5 mg/kg body weight twice weekly for 3 weeks (cumulative dose: 15 mg/kg) (Akolkar et al., 2017) and 0.1 ml distilled water by gavage 5 days a week for 3 weeks.
Group 3: Vitamin D-supplemented group (Vit D) (n=16):
Other data
| Title | Effect of Vitamin D Supplementation on Doxorubicin-Induced Cardiotoxicity in Rats | Other Titles | تأثير إعطاء فيتامين (د) على السمية القلبية الناتجة عن الدوكسوروبيسين فى الفئران | Authors | Yasmin Mohammed Khaled Amin | Issue Date | 2019 |
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