(Prophylactic Use Of Tranexamic Acid To Reduce Blood Loss In Hysterectomy For Benign Causes (Randomised Controlled Trial

Abstract

Background: Hysterectomy is one of the most frequently performed major gynecological surgical procedures. Even when the indication for the procedure is benign, relatively high complication rates have been reported. Perioperative bleeding seems to represent the most common cause of complications. Tranexamic acid is an antifibrinolytic agent that has shown to effectively reduce bleeding complications within other surgical and medical areas. However, knowledge about the drug’s effect in relation to benign hysterectomy is still missing. Aim of the Work: This study aims to assess the efficacy of tranexamic acid as antihemorrhagic agent in decreasing intraoperative bleeding in women undergoing hysterectomy for benign causes. Subjects and Methods: A prospective randomized controlled trial was conducted at gynecological department of Ain Shams university Maternity Hospital. A total of 187 women were consecutively screened for elligability, 23 were excluded owing to exclusion criteria, 4 declined to participate. subsequently, 160 women were successfully randomized. All women scheduled for benign hysterectomy including; leiomyomas, abnormal uterine bleeding, endometriosis, pelvic relaxation and chronic pelvic pain aging between 40-55 years (premenopause) were potentially eligible to participate in the study