Dexmedetomidine versus Nitroglycerine Effect on Emergence Hypertension in Cranial Surgeries

Abstract

The goals of neuro-anesthesia are providing good operating conditions and ensuring stable cerebral hemodynamics. During recovery, abrupt increases in arterial blood pressure can pose a risk for postoperative hematoma. Moreover, fast recovery from anesthesia is often preferred to allow immediate neurological evaluation. Alpha2-Adrenergic agonists as dexmedetomidine has been introduced to clinical anesthesia for their sympatholytic, sedative, anesthetic sparing and hemodynamic stabilizing properties. Dexmedetomidine is increasingly used as an anesthetic adjuvant because of its analgesic properties, cooperative sedation, and lack of respiratory depression. This study was undertaken to assess and compare the hemodynamic and recovery responses to extubation after intravenous injection of study drugs (dexmedetomidine and nitroglycerine) in intracranial surgery.