Association between letrozole dose and pregnancy rate in clomiphene-resistant women with polycystic ovary syndrome randomized controlled trial
Kholoud Rashad El Sharnobi;
Abstract
Abstract
Among couples experiencing difficulty conceiving, unexplained infertility is a fairly common diagnosis, occurring in approximately 10–20% of cases. One of the options available to women with unexplained infertility is ovulation induction, which is most commonly achieved using clomiphene citrate.
However, clomiphene citrate can produce side effects, such as hot flushes and adverse effects on the cervical mucus and endometrium, due mostly to its long half-life and anti-oestrogenic effects. More recently, the aromatase inhibitor letrozole has been investigated as a possible alternative, either as a first treatment or in patients in whom clomiphene has been ineffective
Among couples experiencing difficulty conceiving, unexplained infertility is a fairly common diagnosis, occurring in approximately 10–20% of cases. One of the options available to women with unexplained infertility is ovulation induction, which is most commonly achieved using clomiphene citrate.
However, clomiphene citrate can produce side effects, such as hot flushes and adverse effects on the cervical mucus and endometrium, due mostly to its long half-life and anti-oestrogenic effects. More recently, the aromatase inhibitor letrozole has been investigated as a possible alternative, either as a first treatment or in patients in whom clomiphene has been ineffective
Other data
| Title | Association between letrozole dose and pregnancy rate in clomiphene-resistant women with polycystic ovary syndrome randomized controlled trial | Other Titles | العلاقه بين جرعات الليتروزول ومعدلات حدوث الحمل لدي المرضي الائي يعانين من مقاومة عقار الكلوميفين سترات ومتلازمة تكيسات المبيضين | Authors | Kholoud Rashad El Sharnobi | Issue Date | 2019 |
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