Hemostatic Effect of Intrauterine Instillation of Tranexamic Acid in Hysteroscopic Myomectomy: a double blind RCT

Abstract

Uterine fibroids are the most frequent benign solid tumors that can be discovered in the female genital tract (Okolo, 2008).The age with highest prevalence (which can reach 70% to 80%) is that of 50 (American Association of Gynecologic Laparoscopists, 2012). This study was a randomized controlled double blind clinical trial was conducted during the period from October 2017 to December 2018. The study population was a consecutive series of participants attended the Early Cancer Detection Unit (ECDU) in Ain Shams University Maternity Hospital. The aim of this study was to compare the efficacy of intrauterine instillation of tranexamic acid in hysteroscopic myomectomy.with total number of participants studied was 80 women, divided into two groups; group (A) included 40 women who received TXA in injected media, and group (B) included 40 women who received placebo in distention media. The current study found that both groups were similar at the baseline. There were no differences between groups in the demographic characteristics such as; age, with the mean age in TXA group (37.63± 5.3 years ) vs. (37.17 ± 5.41 years ) in the placebo group with P=0.71, BMI (30.8 ± 2.21kg/m2) and (31.1± 2.20kg/m2) in TXA group and