Histological and Immunohistochemical Study on the Effect of Ghrelin Hormone on Thymic Atrophy Induced by Acute Stress in Male Mouse

Abstract

hymus atrophy and disturbed immunological response in acute stress is a major problem facing our society nowadays. The defective defense mechanism during stress is due to inability of involuted thymus to produce adequate T cell repertoire capable of performing it’s proper function. Many attempts to restore an effective immunological response were in vain. Ghrelin administration during stress waved for a new hope in correction of stress induced thymic atrophy. The aim of our work was to study the effect of stress on thymic architecture, cellularity and function and to prove the possible protective effect of Ghrelin hormone on stressed thymus.