Synthesis of some novel Pyran and Pyridine derivatives and their use as inhibitor for the corrosion of steel in aqueous media, antimicrobial and anticancer.

Abstract

Title of thesis: Synthesis of some novel Pyran and Pyridine derivatives and their use as inhibitor for the corrosion of steel in aqueous media, antimicrobial and anticancer. 1st part: 2-amino-4H-pyran-3-carbonitrile derivative 1 was synthesized by both conventional and microwave methods. Under both microwave and conventional conditions, compound 1 was treated with chloroacetyl chloride, phenyl isocyanate, cyanoacetic acid, benzoyl chloride, T.E.O.F, acetic anhydride/H2SO4, arylidene malononitrile, urea and/or p-aminosulphaguanidine producing pyran derivatives 2-10, respectively. Meanwhile, compound 1 was allowed to react with ethyl bromoacetate, phenacyl bromide, phthalic anhydride, different aromatic amines and/or acetic acid/H2SO4 to produce compounds 11-16, respectively. On the other hand, when compound 1 was allowed to react with maleic anhydride and/or hydrazine hydrate, compounds 17 and 20 were obtained respectively. Reaction of 17 with malononitrile under different conditions gave compounds 18 and 19. While condensation of compound 20 with benzaldehyde gave product 21. The newly synthesized compounds was characterized by the spectroscopic tools IR, 1H-NMR, MS and elemental analysis. Some newly synthesized compounds have been screened in vitro antimicrobial activity against different strains of bacteria and fungi, and also were tested in vitro against two cancer cell lines, mammary gland breast cancer (MCF-7) and colon cancer (HCT-118).