Role of diffusion MRI and Volumetry in assessment of Response of Breast Cancer after Neoadjuvant Treatment

Abstract

Our study was conducted on 22 female patients who presented with breast lumps, then these lesions were assessed by sonomammography and were found to be locally advanced breast neoplastic lesions. This was followed by true cut or fine needle biopsy and invasive breast carcinomas were pathologically proven. All these patients were sent for NAC treatment for down staging of the tumor regarding its volume, cellularity condensations. Pre-treatment MRI diffusion and volumetric assessment of the breast malignant neoplasms whether IDC or ILC was done as well as ADC values measurement for the tumors were taken. And from the available data we conclude that MRI diffusion signal criteria changes (e.g.: from restriction to facilitation) as well as the volumetric assessment changes (especially volumetric reduction exceeding 30%) were highly valuable and of great usefulness. As for the ADC value although show increase among both respondants and non respondants, there was significant increase about 30% at least among the respondants group while it did not exceed 10% among the non respondants group. The combination of both parameters volumetry, diffusion as well as the ADC changes increase the power and ability of the MRI examination as a tool for assessment of breast malignant neoplasms after NAC, and therefore