Efficient delivery of an anti-cancer drug using gelatin nanoparticles

Abstract

Allicin, the most occurring thiosulfinate in fresh garlic powder, was believed to possess various biological activities such as antimicrobial, antiviral, antithrombotic and antihelminthic. Recently, allicin has gripped considerable attention as a potential candidate for cancer treatment and as a strong antioxidant. Unfortunately,allicinisthermo-labile, photosensitive and unstable in alkaline medium, thus representingchallenges in its delivery. Noticeably, gelatin, which is generally regarded as safe (GRAS), has emerged as novel drug delivery platform owing to its unique properties, specially biodegradability, biocompatibility, non-antigenicity, its plentiful sources and exceptional binding ability of different drugs.