DETERMINATION OF TRIGLYCERIDE CONTENT IN SOME LIPOPROTEIN FRACTIONS IN PATIENTS WITH CORONARY ATHEROSCLEROSIS

Abstract

Atherosclerosis is the pathologic condition underlying myocardial infarction and other acute coronary syndromes which are among the leading causes of morbidity, mortality, and health care expenditure in adults. Risk factors that predispose to atherosclerosis can be divided into two categories; modifiable and non modifiable risk factors. Modifiable risk factors include: dyslipidemia, hypertension, smoking, diabetes, overweight, physical inactivity& psychological factors. While non modifiable risk factors include: age, gender and hereditary factors. In human nutrition, TG are the most prevalent glycerol esters encountered. They constitute 95% of fat stores and are the predominant form of glycerol esters found in plasma. The importance of TG in the development of atherosclerosis is currently receiving increasing attention in view of the growing evidence that TG constitute an independent risk factor for cardiovascular disease. TG are recognized to be associated with atherogenesis vm several mechanisms, including effects on endothelial function, macrophage loading, thrombogenesis, and LDL particle size where TG are inversely associated with LDL size. Consequently hypertriglyceridemia is associated with increased prevalence of small dense LDL (phenotype B).