Hyperbaric Oxygen in Infectious Diseases
Rasha Rashad Mohamed;
Abstract
Hyperbaric oxygen therapy consists of expos1ng the patient to intermittent short term 100°/o oxygen inhalation at a pressure greater than 1 atmosphere in a controlled pressurized chamber. It is either single person chamber including patient only or large pressure chamber including patient and medical attendance.
Hyperbaric oxygen increases oxygen tension in tissues to levels that inhibit growth by inhibiting various microbial metabolic reactions. HBO by itself exert direct bacteriostatic and bactericidal effects on microorganisms by the action of oxygen based free radicals (02-, OH, H202) .
These free radicals oxidize proteins and membrane lipids, damage the DNA and inhibit metabolic functions essential for growth strict anaerobic bacteriahave deficient antioxidant defenses (SOD, GSH, catalase) against free radicals so are very susceptible to killing by oxygen.
On contrast, facultative anaerobic and obligate aerobes can detoxify free radicals and so killing of such organisms by the action of phagocytic cells is of great importance. Phagocytosis can occur under low oxygen levels but for killing of organisms by the oxidative burst, oxygen level has
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Hyperbaric oxygen increases oxygen tension in tissues to levels that inhibit growth by inhibiting various microbial metabolic reactions. HBO by itself exert direct bacteriostatic and bactericidal effects on microorganisms by the action of oxygen based free radicals (02-, OH, H202) .
These free radicals oxidize proteins and membrane lipids, damage the DNA and inhibit metabolic functions essential for growth strict anaerobic bacteriahave deficient antioxidant defenses (SOD, GSH, catalase) against free radicals so are very susceptible to killing by oxygen.
On contrast, facultative anaerobic and obligate aerobes can detoxify free radicals and so killing of such organisms by the action of phagocytic cells is of great importance. Phagocytosis can occur under low oxygen levels but for killing of organisms by the oxidative burst, oxygen level has
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Other data
| Title | Hyperbaric Oxygen in Infectious Diseases | Other Titles | الاكسجين ذو الضغط العالى فى الامراض المعدية | Authors | Rasha Rashad Mohamed | Issue Date | 2000 |
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