MICROBIOME IN CIRRHOTIC PATIENTS WITH AND WITHOUT ENCEPHALOPATHY
Waleed Abd AlSamiee Mahmoud;
Abstract
Abstract
Hepatic encephalopathy (HE) is characterized by cognitive impairment and is usually seen in patients with advanced liver disease or porto- systemic shunts. Spectrum of HE varies from minor cognitive dysfunction to lethargy, depressed consciousness and coma.
The pathogenesis of cirrhosis and its complications are closely related to changes in the Intestinal microbiota which has critical functions in multiple aspects of mammalian physiology including regulation of body weight and related metabolic homeostasis, instruction of the immune system, and regulation of epithelial cell responses that are essential to maintain mutualism.
In this study we tried to found the difference in stool microbiome in cirrhotic patients with hepatic encephalopathy, cirrhotic patients without encephalopathy, and non-cirrhotic persons.
Patients with cirrhosis with or without HE were included for a one-time visit, age-matched healthy controls not currently abusing alcohol or on antibiotics and without systemic diseases are also included in this study.
Hepatic encephalopathy (HE) is characterized by cognitive impairment and is usually seen in patients with advanced liver disease or porto- systemic shunts. Spectrum of HE varies from minor cognitive dysfunction to lethargy, depressed consciousness and coma.
The pathogenesis of cirrhosis and its complications are closely related to changes in the Intestinal microbiota which has critical functions in multiple aspects of mammalian physiology including regulation of body weight and related metabolic homeostasis, instruction of the immune system, and regulation of epithelial cell responses that are essential to maintain mutualism.
In this study we tried to found the difference in stool microbiome in cirrhotic patients with hepatic encephalopathy, cirrhotic patients without encephalopathy, and non-cirrhotic persons.
Patients with cirrhosis with or without HE were included for a one-time visit, age-matched healthy controls not currently abusing alcohol or on antibiotics and without systemic diseases are also included in this study.
Other data
| Title | MICROBIOME IN CIRRHOTIC PATIENTS WITH AND WITHOUT ENCEPHALOPATHY | Other Titles | ميكروبات الامعاء في مرضي التليف الكبدي في وجود وعدم وجود الغيبوبة الكبدية | Authors | Waleed Abd AlSamiee Mahmoud | Issue Date | 2018 |
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