Synthesis, Characterization, and Antimicrobial Evaluation of the Novel Triazolotriazolopyridines and Pyridotriazolotriazines

Abstract

The starting compound 2-hydrazinyl-7-(4-methoxyphenyl)-5-oxo-3,5-dihydro[1,2,4]triazolo[1,5-a]pyridine-6,8-dicarbonitrile (5) was efficiently synthesized from 1,6-diamino-4-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile (1). A novel series of polynuclear [1,2,4]triazolo[4′,3′:2,3][1,2,4]triazolo[1,5-a]pyridines 6, 7, 8, 9, 10 and pyrido[1′,2′:2,3][1,2,4]triazolo[5,1-c][1,2,4]triazines 11, 12, 13, 14, 15 have been synthesized. Structures of the newly synthesized products have been deduced on the basis of elemental analysis and spectral data. The synthesized compounds were screened for their antimicrobial activity.