Hydrophilic versus hydrophobic porogens for engineering of poly(lactide-co-glycolide) microparticles containing risedronate sodium
Nasr, Maha; Awad, Gehanne A S; Mansour, Samar; Al Shamy, Abdelhamid; Mortada, Nahed D;
Abstract
The aim of this study was to investigate the effect of two mechanistically different porogens, namely: the hydrophilic hydroxy-propyl-β-cyclodextrin and the hydrophobic porogens (mineral oil and corn oil) in producing open/closed pored engineered polylactide-co-glycolic-acid microspheres suitable for pulmonary delivery of risedronate sodium (RS).
Other data
| Title | Hydrophilic versus hydrophobic porogens for engineering of poly(lactide-co-glycolide) microparticles containing risedronate sodium | Authors | Nasr, Maha ; Awad, Gehanne A S; Mansour, Samar; Al Shamy, Abdelhamid; Mortada, Nahed D | Issue Date | 2013 | Journal | Pharmaceutical development and technology | Volume | 18 | Issue | 5 | Start page | 1078 | End page | 1088 | ISSN | 1083-7450 1097-9867 |
DOI | 10.3109/10837450.2012.693507 | PubMed ID | 22656315 |
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