Synthesis of Pyrano[3,2-c]quinoline-3-carboxaldehyde and 3-(Ethoxymethylene)-pyrano[3,2-c]quinolinone and Their Chemical Behavior toward Some Nitrogen and Carbon Nucleophiles

Abstract

Synthesis of novel 3-(ethoxymethylene)-pyrano[3,2-c]quinolinone and pyrano[3,2-c]quinoline-3- carboxaldehyde was accomplished efficiently via a simple method. These two scaffolds were used as precursors to afford new biologically interesting products in good yield and short reaction times. The chemical reactivity of ethoxy methylene 2 and carboxaldehyde 3 toward different nucleophilic reagents was studied. Structures of the new synthesized compounds were elucidated by their analytical and spectral data.