Prevalence and antimicrobial susceptibility profile of multidrug-resistant bacteria among intensive care units patients at Ain Shams University Hospitals in Egypt—a retrospective study
Alaa Eldin Fahim, Noha;
Abstract
Abstract
Background: The nightmare of the rising numbers of multidrug-resistant organisms (MDROs) requires the
implementation of effective stewardship programs. However, this should be preceeded by making available
evidence-based knowledge regarding the local antimicrobial resistance pattern, which is fundamental. The aim of
the current study is to determine the prevalence of MDRO among different Ain Shams University Hospitals (ASUHs)
intensive care units (ICUs) and detect the resistance profile of the common pathogens.
Results: The 1-year records of a total of 1280 pathogens were studied. The highest number of pathogens were
isolated from blood cultures (44.84%), followed by urine (41.41%) then wound swabs (13.75%). Gram-negative
isolates (57.5%) were more prevalent than gram-positive ones (31.1%). The most frequently isolated pathogens were
Klebsiella spp. (22.5%), Escherichia coli (13.4%), and Coagulase-negative Staphylococci (12.5%). The highest percentage
of resistance among gram-positive organisms was exhibited by penicillin (89.5%) followed by erythromycin (83.98%)
and then cefoxitin (76.52%). None of the isolates showed resistance to linezolid and resistance to vancomycin was
minimal (2.62%). Gram-negative isolates exhibited high overall resistance to all used antibiotic classes. The least
frequency of resistance was recorded against nitrofurantoin (52.5%), amikacin (58.01%), followed by imipenem (59.78%)
and meropenem (61.82%). All isolates of Pseudomonas and Acinetobacter showed 100% susceptibility to colistin.
Conclusions: The prevalence of antibiotic resistance in Ain Shams University Hospitals (ASUHs) was high among both
gram-negative and gram-positive organisms. This high resistance pattern foreshadows an inevitable catastrophe that
requires continuous monitoring and implementation of effective antibiotic stewardship.
Background: The nightmare of the rising numbers of multidrug-resistant organisms (MDROs) requires the
implementation of effective stewardship programs. However, this should be preceeded by making available
evidence-based knowledge regarding the local antimicrobial resistance pattern, which is fundamental. The aim of
the current study is to determine the prevalence of MDRO among different Ain Shams University Hospitals (ASUHs)
intensive care units (ICUs) and detect the resistance profile of the common pathogens.
Results: The 1-year records of a total of 1280 pathogens were studied. The highest number of pathogens were
isolated from blood cultures (44.84%), followed by urine (41.41%) then wound swabs (13.75%). Gram-negative
isolates (57.5%) were more prevalent than gram-positive ones (31.1%). The most frequently isolated pathogens were
Klebsiella spp. (22.5%), Escherichia coli (13.4%), and Coagulase-negative Staphylococci (12.5%). The highest percentage
of resistance among gram-positive organisms was exhibited by penicillin (89.5%) followed by erythromycin (83.98%)
and then cefoxitin (76.52%). None of the isolates showed resistance to linezolid and resistance to vancomycin was
minimal (2.62%). Gram-negative isolates exhibited high overall resistance to all used antibiotic classes. The least
frequency of resistance was recorded against nitrofurantoin (52.5%), amikacin (58.01%), followed by imipenem (59.78%)
and meropenem (61.82%). All isolates of Pseudomonas and Acinetobacter showed 100% susceptibility to colistin.
Conclusions: The prevalence of antibiotic resistance in Ain Shams University Hospitals (ASUHs) was high among both
gram-negative and gram-positive organisms. This high resistance pattern foreshadows an inevitable catastrophe that
requires continuous monitoring and implementation of effective antibiotic stewardship.
Other data
| Title | Prevalence and antimicrobial susceptibility profile of multidrug-resistant bacteria among intensive care units patients at Ain Shams University Hospitals in Egypt—a retrospective study | Authors | Alaa Eldin Fahim, Noha | Keywords | Multidrug resistance;Susceptibility profile;ICU;Prevalence;Egypt | Issue Date | 29-Mar-2021 | Publisher | Springer open | Journal | Journal of the Egyptian Public Health Association | Volume | 96 | Issue | 7 | DOI | 10.1186/s42506-020-00065-8 |
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