Novel pyridazine derivatives: Synthesis and antimicrobial activity evaluation
Hassan, Hemat; N.G. Kandile; M.I. Mohamed; H. Zaky;
Abstract
A general method for the preparation of new hydrazones is reported. The 1-[4-(2-methoxybenzyl)-6-aryl
pyridazin-3(2H)-ylidene] hydrazines or their tautomeric structures (1a–d) were condensed with different
aldehydes, dialdehydes, ketones, a-dicarbonyl compounds and simple carbohydrates to afford the
hydrazones and dihydrazones (2a–d), (3a–d), (4a–d), (5a–d), (6d), (7c), (8a–d), (9a–d), (10a–d), (11a–d), (12a,c,d),
(13a–d), (14a–d), (15a–d), (16a–d) and (17a–d)
pyridazin-3(2H)-ylidene] hydrazines or their tautomeric structures (1a–d) were condensed with different
aldehydes, dialdehydes, ketones, a-dicarbonyl compounds and simple carbohydrates to afford the
hydrazones and dihydrazones (2a–d), (3a–d), (4a–d), (5a–d), (6d), (7c), (8a–d), (9a–d), (10a–d), (11a–d), (12a,c,d),
(13a–d), (14a–d), (15a–d), (16a–d) and (17a–d)
Other data
| Title | Novel pyridazine derivatives: Synthesis and antimicrobial activity evaluation | Authors | Hassan, Hemat ; N.G. Kandile; M.I. Mohamed; H. Zaky | Keywords | Hydrazones, Pyridazine, Aldehydes, Carbohydrates, Dihydrazones, Antimicrobial activity | Issue Date | 11-Oct-2008 | Journal | European Journal of Medicinal Chemistry | Volume | 44 | Start page | 1989 | End page | 1996 |
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