SCREENING FOR MYCOTOXINS IN CHRONIC LIVER DISEASES

Abstract

This study include@ 70 patients with chronic liver disease, 35

patients with hepatocellullr carcinoma on top of liver cirrhosis and 60 healthy subjects as a cobtrol group. They were evaluated clinically, sonographically and by laJoratory investigations.

Sorum "mpk' wore o.lod fm mycotoxin'by qmliitativo (thin lay" chromatography method) and quantitative (High Performance Liquid Chmmntogmphy mcthod)l

Our results revealed that:

1- Aflatoxin Bb B2, Ph Gb G2 , Q1 streigmatocystin and citmin were detected in the serum samples of the patients and the controls.

2- By qua1I.tatJ.ve esti.mati.On of

aflatoxm• s there was no st•gm•fticant

difference between tJe patients and controls (T-test, P= 0.656) but by quantitative estimatidn there was a significant difference between the mean level in patienJs with HCC (J 1.43 ng/5 ml), patients with CLD (8.76 ng/5 ml) and cohtrols (3.11 ng/5 ml).

3- There was no statistical difference between the mean level of • aflatoxins in patients lith CLD and those with HCC (p= 0.235). 4- The mean level of aflatoxin B 1 was significantly higher in patients with HCC (J 1.38 nJ/5 ml) than those with CLD (5.3 ng/5 ml) versus

the control group (3.42 ng/5 ml).

5- Other types of

mycotoxm.

s as sten.gmatocystm.

d .. cttmm

were

detected in the seruJ in few number of patients and control group.