Salivary Pepsin as a Non-Invasive Rapid Diagnostic Test Versus Upper GIT Endoscopy For Diagnosis Laryngopharyngeal Reflux Disease

Abstract

Abstract Background: Laryngopharyngeal reflux (LPR) is the retrograde movement of gastric contents (acid and pepsin) into the laryngopharynx leading to symptoms in the larynx or the hypopharynx. Typical Laryngopharyngeal reflux symptoms include dysphonia, hoarseness, dysphagia, globus pharyngeus, chronic cough chronic throat clearing, excessive throat mucus, sialorrhea, sensation of postnasal drainage, dysgeusia, halitosis, throat pain and heart burn. Aim of the work: to assess the value of Pepsin measurement in the sputum/saliva as a non-invasive method for diagnosing Laryngopharyngeal reflux (LPR).