ORGAN TOXICITY OF SOME ANALGESIC DRUGS AND THE ROLE OF MISOPROSTOL AS A PROTECTIVE AGENT
Osama Abdel-Aziz Hassan;
Abstract
This experimental work aimed at evaluation of the acute and chronic toxic effects of acetaminophen on the liver and kidney and the study of the
chronic effects of analgesic mixture containing acetaminophen, aspirin and
•.
caffeine on these organs together with evaluation of the protective effect of
misoprostol on toxicity of these drugs.
The following toxicological experimental studies were canied out:
A. Acute, toxicity study:
.•
" This study was carried out on 240 albino rats divided into 12 groups.
Each group consists of 20 rats.
Grou1l I : Negative control group which was not subjected to treatment by any drug.
Group II: Placebo group, the animals of this group received 20% tween
80 I.P. (few drops of tween 80 inlml distilled water).
Group III: The animals of this group was given misoprostol (25 tg/kg) J.P.
chronic effects of analgesic mixture containing acetaminophen, aspirin and
•.
caffeine on these organs together with evaluation of the protective effect of
misoprostol on toxicity of these drugs.
The following toxicological experimental studies were canied out:
A. Acute, toxicity study:
.•
" This study was carried out on 240 albino rats divided into 12 groups.
Each group consists of 20 rats.
Grou1l I : Negative control group which was not subjected to treatment by any drug.
Group II: Placebo group, the animals of this group received 20% tween
80 I.P. (few drops of tween 80 inlml distilled water).
Group III: The animals of this group was given misoprostol (25 tg/kg) J.P.
Other data
| Title | ORGAN TOXICITY OF SOME ANALGESIC DRUGS AND THE ROLE OF MISOPROSTOL AS A PROTECTIVE AGENT | Other Titles | التأثير السام لبعض الأدوية التى تستخدم كمسكنات للألم على بعض أعضاء الجسم مع دراسة التأثير الوقائى والعلاجى لعقار الميزوبروستول | Authors | Osama Abdel-Aziz Hassan | Issue Date | 2002 |
Attached Files
| File | Size | Format | |
|---|---|---|---|
| B14240.pdf | 1.05 MB | Adobe PDF | View/Open |
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