Effect of low-dose aspirin on mid-luteal phase Uterine Artery blood flow in women with recurrent pregnancy loss

Abstract

ecurrent pregnancy loss is defined as two or more consecutive pregnancy loses prior to completion of 20 weeks gestation. It is a common and frustrating pregnancy complication, which affects 1% to 5% of reproductive women worldwide (Shahine and Lathi, 2015). Assessment of uterine blood flow has become potentially valuable for evaluating the functional capacity of the endometrium during the implantation window after the introduction of Doppler methods to clinical practice (Pietropolli et al., 2015). The pulsatility index of uterine artery has been known to diminish progressively during the luteal phase during which implantation occurs (Habara et al., 2002). Decreased uterine blood flow is considered a causative factor in recurrent pregnancy loss (Koo et al., 2015).