Evaluating the effect of insulin-dependent diabetes on the hypothalamic-pituitary-testicular axis and seminal parameters under electron microscopy

Abstract

20 cases with IDDM (Group-A) and 10 healthy controls recenlly fertile (Group-B) were selected to study . the effect of IDDM on boUt the hypothalamic-pituitary-gonadal axis and the semen parameters under the electron microscope. B<itli patients and controls did hormonal assay (prolactin testosterone, FSH and LH), semen analysis under light and electron microscopy and GnRH test. There was a significant difference between both groups wiUt lower level of testosterone, prolactin and FSH and higher LH in (Group-A). This means that IDDM may affect the hormonal axis at different levels and that this effect mny be, even partially a cause of.the effect of IDDM on the semen parameters under the electron microscope.