Serum Amyloid A level in women with unexplained infertility

Abstract

By various molecular and cellular research efforts it was displayed that folliculogenesis, ovulation, and corpus luteum formation is considered as an inflammatory processes that hav raised the research interst to investigate that serum amyloid A as an inflammatory mediator to reveal its possible role in infertility . ( Koga et al., 2008) The current research study have been conducted at Ain Shams University Maternity Hospital during the period from September 2018 to April 2019. Women approached were recruited from outpatient clinic of Ain Shams University Maternity Hospital. The recruited 90 research study subjects have been divided into two research groups as follows: • Group I: including (45) women seeking for fertility. • Group II: including (45) fertile women seeking for method of contraception. Serum amyloid A was statistically significantly higher among the unexplained research group versus control group ( SAA had excellent discriminative value with an area under the ROC curve (AUC) of 0.992 (95% CI = 0.945 to 1.000, P-value <0.0001). A best cutoff criterion is SAA of 28.7 mg/l (sensitivity = 98%, specificity = 96%, J-index = 0.93)) denoting that amyloid A as an acute phase inflammatory modulator is higher among the unexplained research group reflecting a form of chronic inflammatory process in those category of cases.