Effect of Endometrial Injury on Pregnancy Rate in Women with Unexplained Infertility in Cycles Stimulated by Letrozole: Randomized Controlled Trial

Abstract

Infertility is a continuous challenge for all gynecologists worldwide. Infertility is defined as the failure to achieve pregnancy after a year (in women less than 35 years old) or 6 months (in women more than 35 years old) of unprotected sexual intercourse. Studies show that infertility affects about 15 to 20 percent of couples worldwide (Evers, 2002). Unexplained infertility, usually refers to a diagnosis (or lack of diagnosis) made in couples in whom all the standard investigations such as tests of ovulation, tubal patency and semen analysis are normal (Smith et al. (2003). The incidence of unexplained infertility varies in different studies but is usually 10-20 % (Aboulghar et al., 2001).