A study of the effects of oral magnesium on the clinical and biochemical parameters and on foeto-placental circulation in pregnancy-induced hypertension.

Abstract

This work started with a review of literature on hypertensive disorders m pregnancy, their classification, incidence, predisposing factors, aetiological theories, as well as pathophysiology. The studies on the aetiology of pre-eclampsia have been focused on the role of immunological mechanisms, vasoactive compounds, prostaglandins, trace elements, as well as a possible endothelial dysfunction.

Magnesium has an important role in human metabolism. Serum magnesium levels decline during normal pregnancy, and its requirements increase during pregnancy and lactation. A compromised magnesium nutritional status may be involved m the pathophysiology of pre­ eclampsia.

Zinc is an essential trace element, necessary for maintenance of growth and regulation of normal physiological functions.

Cadmium is a trace element,•the toxicity of which has been shown to i . have a role in precipitation of hypertension. A significant alteration in the serum levels of cadmium and zinc has been demonstrated in cases of pregnancy-induced hypertension.

The aim of this work was to evaluate the•'I"ole of oral magnesium citrate as a new therapeutic modality in PIH. The study was carried on twenty primigravidae in their third trimester; attending the Shatb)r University Maternity Hospital. They all suffered mild pre-eclampsia with blood pressures > 140/90 and< 160/110, measure.d six hourly for 24 hours, and ...