Comparative Study between the Efficacy of Platelet Rich Plasma with Methotrexate and Methotrexate Alone in Treatment of Chronic Plaque Psoriasis

Abstract

soriasis affects up to 3% of the world's population or more than 125 million people. There is an urgent need for new treatment strategy, as up to 50% of patients are not satisfied with current therapies. We evaluated the efficiency of combined platelet rich plasma (PRP) and methotrexate (MTX) injection in management of psoriasis vulgaris and combared it with methotrexate injection only. Fourty patients with chronic plaque psoriasis were divided into two groups. Tweenty patients were assigned into combinational treatment group (PRP + MTX) and monotherapy group (MTX alone) consisted of another tweenty patients. All patients in combinational therapy group received autologous intralesional PRP at 0,4 and 8 weeks combined with methotrethate im injection once every week for 12 weeks, while patients in monotherapy group received only methotrexate im injection once every week for 12 weeks. Evaluation of treatment response was done through comparing digital photographs, Psoriasis Area Severity Index (PASI) and Dermatology life Quality Index (DLQI) score at weeks 0, 6 and 12 weeks after treatment. All encountered adverse effects were recorded. Patients treated with combined PRP/MTX showed significant improvement at each visit regarding comparing patients photographs, PASI and DLQI scores than patients treated with MTX only.