Study The Role Of Erythrocyte Glutathione Transferase As A Potential Marker Of Hemodialysis Adequacy

Abstract

urvival in ESRD patients is made possible by removal of uremic solutes by dialysis, uremic toxins include small water-soluble compounds such as urea, protein-bound solutes or larger middle molecules such as beta 2-microglobulin (Vanholder et al.,2014). An ideal dialysis therapy should remove all of these compounds However, only small toxins are easily removed by all dialysis techniques (Krieter et al.,2010). Kt/V cannot represent the removal of other solutes and fluid, so this parameter should not be used alone as the sole indicator of dialysis adequacy (Basile et al.,2012). Thus, other dialysis adequacy biomarkers have been identified such as Erythrocyte Glutathione transferase (E-GST) which is an enzyme able to detoxify the cell from endogenous and exogenous toxic compounds by using glutathione (GSH) or acting as a ligandin for toxins (Bocedi et al.,2019) Aim of the study: To verify whether E-GST is a novel biomarker of hemodialysis adequacy in different dialysis techniques {(standard bicarbonate hemodialysis (HD) and (HDF)} or complementary to the Kt/V urea parameter.