Effect of Experimentally Induced Chronic Kidney disease on Skeletal, Cardiac and Smooth Muscle fibers of albino rat. A light and transmission electron microscopic study.

Abstract

Chronic kidney disease (CKD), or chronic renal failure (CRF) as it was historically termed, includes all degrees of decreased renal function. Skeletal muscle atrophy frequently complicates the course of CKD and is associated with excess morbidity and mortality. Cardiovascular diseases have been reported to be the leading causes of death in CKD patients. Chronic Kidney Disease was also reported to be associated with an increased incidence of acid-related gastrointestinal disorders. The clinical course and pathophysiology of the disease is complex, so this study aimed to evaluate the effect of CKD on the different types of muscular tissues of the body: skeletal, cardiac and smooth muscles of male Wistar albino rat. The experiment was conducted on 20 adult male albino rats with an average weight range from 220 to 250 grams. They were divided into two groups: Group I: Control group: This group included 10 rats that received physiological saline intramuscular injection, once daily for 28 consecutive days, in a dose equivalent to that taken in group II. The rats of this group were sacrificed after 28 days of the beginning of the experiment. Group II: Group of CKD: consisted of ten rats that were given Gentamicin intramuscular injection for induction of CKD. Gentamicin was given as Gentamycin