Correlation between Serum Anti-Müllerian Hormone Levels and Antral follicle count in prediction of clinical pregnancy in women with unexplained infertility undergoing ICSI cycles

Abstract

AMH, also known as mullerian-inhibiting substance, is a dimeric glycoprotein that belongs to the transforming growth factor-β family. It is widely accepted that the reduction of AMH levels in serum is the first indication for decline in the follicular reserve of the ovaries and can be measured in the blood at any time in the menstrual cycle due to its stability (Battikhi, 2017). Over the past decade there have been hundreds of publications regarding the ability of serum anti-Müllerian hormone level (AMH) to predict a positive pregnancy test in ICSI programe. Though the results have so far been controversial, it can be considered as established knowledge that serum AMH levels are positively correlated with the total number of retrieved oocytes (Barad et al., 2011; Reijnders et al., 2016). So that AMH would seem in fact to be highly predictive of poor ovarian response (Honnma et al., 2012).