THE ROLE OF METFORMIN IN PREVENTION OF FIRST TRIMESTERIC MISCARRIAGE IN WOMEN WITH POLYCYSTIC OVARY SYNDROME (Randomized Controlled Study)

Abstract

Women with insulin resistance are at increased risk of hyperinsulinemia, PCOS, and hyperandrogenism. They are also at risk of reduced fertility due to ovulatory dysfunction and suboptimal hormonal profiles that may impair conception and implantation. This emphasizes the need for a treatment using drugs such as metformin, which will actively reduce insulin resistance, and will restore ovulatory cycles and reduce early pregnancy loss. In addition to this there is accumulating evidence suggesting that this drug is probably safe in the first trimester of pregnancy despite the traditional response that all oral hypoglycemic agents are contraindicated in pregnancy. The findings of this study support the previous reports that stated that decreasing insulin resistance with metformin in women with PCOS decreases the rate of early pregnancy loss. In our analysis, it is observed that there was a dramatic reduction in the rates of early pregnancy loss in the metformin group compared with the control group. The early pregnancy loss rate of 10.8% is comparable to the rate of 10 – 20% repoted in normal women. While in the control group early pregnancy loss rate was 42.2%.