Neutrophil CD11b Expression as a Marker for Early Diagnosis of Neonatal Sepsis

Abstract

Neonatal sepsis remams a maJor cause of morbidity and mortality in neonatal period, with high incidence in developing countries 5.6 per 1000 live births.

Clinical diagnosis of sepsis is not easy because symptoms and signs are not specific and dramatic deterioration of the clinical condition may occur vf ry rapidly before blood culture results are available.

The aim of this study is to determine the CD11b neutrophil expression in high risk infants in NJCU <md its value in detection of early onset - neonatal sepsis. Our study was carried on 23 neonates presentiing with clinical and laboratory manifestation of sepsis and 7 with suspected manifestation of sepsis and 10 matched normal healthy neonates used as a control group. All cases were subjected to : Medical history, clinical examination, complete blood picture ( CBC ), C­ reactive protein ( CRP ), blood culture, chest x-ray and