Correlation between Hypervolemia, Left Ventricular Hypertrophy and Fibroblast Growth Factor- 23 in Prevalent Hemodialysis Patients

Abstract

his cross sectional study was conducted in Ain shams university hospital and al Agoza hospital, on 60 prevalent hemodialysis patients in December 2018. Three patient from high IDWG group died during the study. Patients were divided into two groups according to intradialytic weight gain (IDWG): Group I (low IDWG): Patients with absolute weight gain < 3 kg. Group II (high IDWG): patients with weight gain ≥ 3 kg.. In this study we found that: • There was a significant difference between the two groups in SBP, serum Cr, (PO4)3-, PW, LA and LVMI that was higher in high IDWG group than low IDWG group. As regards FGF-23: • In all patient group; FGF-23 had a positive correlation with (weight gain, systolic blood pressure, diastolic blood pressure, mean arterial blood pressure, Na+, (PO4)3-, PTH, IVS, PW, LA and LVMI) but had a negative correlation with HB %. • In low IDWG group; there was a positive correlation between FGF-23 and (weight gain, Na+, (PO4)3-, PTH, ferritin, IVS and LVMI) but had a negative correlation with (duration of dialysis and HB).