GASTRODUODENAL LESIONS AMONG PATIENTS WETH LIVER CIRRHOSIS HARBOURING CY'TOMEGALOVIRUS AND HELICOBACTER PY'LORI

Abstract

Patients with liver cirrhosis showing potentially variable degrees of gstroduodenal lesions. H. pylori is now recognized as a major factor in the pathogenesis of gastroduodenal disease. It has been implicated as the causative agent for. most duodenal and gastric ulcers and it also causes gastritis, duodenal ulcers and gastric cancer.

Human cytomegalovirus is one of the herpesviruses which is aquired

throughout life. In immunocomptent individuals, it remains latent however • when cellular immune functions are depressed it can cause severe and fatal infections.

The aim of this study is to evaluate the role of H. pylori and CMV in the pathogenesis of gastroduodenal lesions in patients with liver cirrhosis.

Fifty two patients were classified into two groups.

Group 1: Twenty six patients with liver cirrhosis with hematemesis or melena or history of them. • Group II: Twenty six patients with liver cirrhosis without history of hematemesis or melena.

Twenty healthy individuals were selected as a controls.

All patients and controls were subjected to full history and clinical examination, laboratory profile, abdominal ultrasonography, upper endoscopy, biopsies from antrum and duodenum were taken for urease testing and histopathological examination, serological assay for CMV lgM antibodies e using ELISA test.