Role of Epithelial-to-Mesenchymal Cells Transition in Type 2 Diabetic Patients with Nephropathy

Abstract

Diabetes mellitus (DM) has routinely been described as a metabolic disorder characterized by hyperglycemia that develops as a consequence of defects in insulin secretion, insulin action, or both. People with diabetes have an increased risk of developing a number of serious life-threatening health problems resulting in higher medical care costs and reduced quality of life (International Diabetes Federation) (IDF, 2017). Diabetes is justly recognized as a developing global epidemic, representing one of the chief reasons of morbidity and mortality worldwide. It has the potential to cause serious complications due to its insidious and chronic nature (Papatheodorou et al., 2015).