Breast Conservation Surgery versus Modified Radical Mastectomy in the Management of Non Metastatic Inflammatory Breast Cancer

Abstract

nflammatory breast cancer (IBC), the most lethal form of breast cancer, constitutes 1–6% of all breast cancers in the United States. In Egypt, this occurrence is as high as 10%, and this justifies a collective international effort to better understand the distinctive biological, clinical aspect of IBC as well as to discover novel targets for this unique and rare disease entity. The risk for misdiagnosis of IBC is unusually high and increased by many factors. One factor being that the clinical and pathological symptoms does not exist uniformly in all cases of IBC. Multimodality therapy is the standard in management of non metastatic inflammatory breast cancer patients including neoadjuvant chemotherapy (Anthracycline and taxane based regimens) and endocrine therapy (according to the tumor receptors status) and mastectomy followed by post mastectomy radiation.