The relationship of Serum IgE and IL-10 in cases of Allergy - Solid tumors
Reham Mohamed El Shabrawy;
Abstract
The suggested relation between allergy and tumors rose in 1950. The term AllergoOncology officially rose in 2006 to address the field considered with studying the significance of IgE mediated immune responses against tumors aiming to identify IgE-based treatment options against tumors.
Theoretically, allergy and oncology may represent two opposite concepts: Allergy represents a hyper active state of the immune system, while tumor cells develop as a consequence of failure of the body to mount immune mechanisms effective enough to eliminate these cells. Despite of these facts, researches tried to find out a possible framework for the relation between allergy and cancer, yield controversial results.
We aimed to assess the relation between allergy and solid cancer and to assess the association between serum total IgE and IL-10 levels in cases of allergic diseases and solid tumors.
This case-control study included 50 patients and 50 healthy controls in the period. For each patient, the diagnosis of cancer was made by expert oncologists according to the international guidelines. Then full history was taken to detect symptoms of allergy or previously diagnosed allergic diseases. We then underwent skin prick test or measuring of specific IgE in serum for allergic patients, measurement of serum total IgE by ELISA, and measurement of serum IL-10 by ELISA.
Theoretically, allergy and oncology may represent two opposite concepts: Allergy represents a hyper active state of the immune system, while tumor cells develop as a consequence of failure of the body to mount immune mechanisms effective enough to eliminate these cells. Despite of these facts, researches tried to find out a possible framework for the relation between allergy and cancer, yield controversial results.
We aimed to assess the relation between allergy and solid cancer and to assess the association between serum total IgE and IL-10 levels in cases of allergic diseases and solid tumors.
This case-control study included 50 patients and 50 healthy controls in the period. For each patient, the diagnosis of cancer was made by expert oncologists according to the international guidelines. Then full history was taken to detect symptoms of allergy or previously diagnosed allergic diseases. We then underwent skin prick test or measuring of specific IgE in serum for allergic patients, measurement of serum total IgE by ELISA, and measurement of serum IL-10 by ELISA.
Other data
| Title | The relationship of Serum IgE and IL-10 in cases of Allergy - Solid tumors | Other Titles | علاقة مستوى الاجسام المضادة "اي" بالمصل و الانترلوكين 10 في حالات أمراض الحساسية والأورام الصلبة | Authors | Reham Mohamed El Shabrawy | Issue Date | 2020 |
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