“Diode Laser Application versus Ibuprofen in Treatment of Ligature-Induced Periodontitis in Albino Rats. Histological and Immunohistochemical study”

Abstract

Introduction and Review of the Literature: Plaque induced periodontitis is the second most common oral disease worldwide after dental caries (Petersen, 2003). Documents from animal experiments proved that NSAIDs can reduce the inflammation and the rate of resorption of alveolar bone thus, stabilize the periodontal condition (Salvi & Lang, 2005). In the last 10 years, diode laser also has been highly recommended as a treatment modality for periodontal inflammatory diseases due to its anti-inflammatory effect, ability to accelerate the healing process and its pain reduction ability (Aykol et al., 2011). Aim of study The Aim of the study was to compare the efficacy of diode laser versus ibuprofen in treatment of ligature induced periodontitis in albino rats. Materials and Methods 84 animals were randomly allocated to four equal groups in three sacrifices periods (sacrifice at 7, 15, and 30 days) of 7 animals per group (Oliveira et al., 2017). Group I was not subjected to any procedures (negative control group). Group II was subjected to the ligature procedure but did not receive any kind of treatment (positive control group). Group III was subjected to the ligature procedure and received laser irradiation once for treatment after ligature removal (laser treated group). Laser treatment was performed by using a 940 nm diode laser at 1.5 W with a pulse interval of 20 ms and pulse length of 20 ms delivering 20 s/ cm2 and 15 J/cm2 of energy (Saglam et al., 2014). Group IV was subjected to the ligature procedure and received ibuprofen syrup by gastric gavage once daily for only 4 successive days (20mg/kg) (Liles and Flecknell, 1992). After treatment, Group II, III and IV were equally subdivided into three subgroups A, B and C respectively (7 rats each) for termination (Theodoro et al., 2016).