Evaluation of the efficacy of bone marrow derived- mesenchymal stem cells co-cultured with nanomaterials in the management of osteoporosis in rat model

Abstract

The principal goal of this study was to evaluate the osteoinductive efficacy of the selected nanomaterials (Au-NPs, Au/HA-NPs, C/HA-NPs, HA-NPs and C-NPs) on the differentiation of rat bone marrow-derived mesenchymal stem cells (BM-MSCs) into osteoblasts. Moreover, this study was extended to elucidate the therapeutic role of osteoblasts' infusion, generated from culturing BM-MSCs in either osteogenic medium alone or supplied with the selected nanomaterials, in alleviating the bone remodeling events in primary osteoporosis induced in the adult female rats. This was achieved through utilizing biochemical, molecular genetics, DEXA and histological techniques.