Peri-Operative Beta Blocker and Its Effect on Coronary Artery Bypass Graft Patients Outcome after Surgery

Abstract

eta-adrenergic receptor blockers have been studied for minimizing the effects of the circulating catecholamine and several studies have shown the efficacy of such drugs in decreasing postoperative morbidity and mortality. It is proved that beta-adrenergic antagonists (β-blockers) attenuate the extent of injury to myocardium during periods of ischemia and reperfusion and reduce perioperative cardiovascular complications such as myocardial ischemia, stroke and heart failure by neutralization of tachycardia and catecholamine induced hypertension. The function of ventricles can be improved by early beta-blocker administration during Cardio-Pulmonary Bypass (CPB). The current study high lightened the effect of peri-operative beta blocker on the outcome of patients undergoing CABG surgery , and found that it is beneficial regarding recovering of automatic re-beat regaining of sinus rhythm as initial reperfusion rhythm in 72% compared to 48%in control group, improving the ventricular functions, decreasing the incidence of post-operative arrythmias from 40% to 20%, decreased the duration of hospital and ICU stay.