ROLE OF DIFFUSION WEIGHTED MRI IN ASSESSMENT OF TREATMENT RESPONSE TO CHEMOTHERAPY IN PATIENTS WITH OSTEOGENIC SARCOMA
Kareem Mahmoud Mohamed Gaber;
Abstract
Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. Currently, 10-year overall survival rates are 60% to 70% for all patients and only approximately 20% for patients with metastatic disease.
Aim of the Work: To investigate whether diffusion-weighted imaging (DWI) is useful for monitoring the therapeutic response after chemotherapy in osteosarcoma by comparing the ADC values pre and post chemotherapeutic treatment. To determine if osteosarcomas change their water diffusion during preoperative chemotherapy in relation to the amount of tumour necrosis.
Patients and Methods: This is a retrospective study included 30 patients (18 females & 12 males), their ages range from 7 to 36 years. Mean age 14.8 years. The study was performed Radiology Department at Ain-Shams University Hospitals between September 2018 & Dec 2019.
Results: Most of cases about 50 % show partial response according to RECIST criteria.
Conclusion: Chemotheraphy is effective in reducing size, increase tissue breakdown and improvement of cases of osteosarcomas according to results of this study.
Aim of the Work: To investigate whether diffusion-weighted imaging (DWI) is useful for monitoring the therapeutic response after chemotherapy in osteosarcoma by comparing the ADC values pre and post chemotherapeutic treatment. To determine if osteosarcomas change their water diffusion during preoperative chemotherapy in relation to the amount of tumour necrosis.
Patients and Methods: This is a retrospective study included 30 patients (18 females & 12 males), their ages range from 7 to 36 years. Mean age 14.8 years. The study was performed Radiology Department at Ain-Shams University Hospitals between September 2018 & Dec 2019.
Results: Most of cases about 50 % show partial response according to RECIST criteria.
Conclusion: Chemotheraphy is effective in reducing size, increase tissue breakdown and improvement of cases of osteosarcomas according to results of this study.
Other data
| Title | ROLE OF DIFFUSION WEIGHTED MRI IN ASSESSMENT OF TREATMENT RESPONSE TO CHEMOTHERAPY IN PATIENTS WITH OSTEOGENIC SARCOMA | Other Titles | دور الرنين المغناطيسى بخاصية الانتشار فى متابعة العلاج الكميائى للمرضى المصابين بالورم العظمى الغرنى | Authors | Kareem Mahmoud Mohamed Gaber | Issue Date | 2020 |
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