Histological and Histochemical Study of the Effect of Chlorpyrifos on the Myocardium and the Coronary Arteries of Albino Rats and the Possible Protective Effect of Ascorbic Acid

Abstract

Chlorpyrifos (diethyl 3,5,6-tricholoro-2-pyridyl phosphorothioate) is one of the pesticides which are used to kill pests of both plants and animals that interfere with our comfort and health.

Poisoning occurs in various setting, accidental ingestion especially by children, ingestion of contaminated food, intentional ingestion in cases of suicidal attempt, accidental spillage of pesticides on skin and clothing and inhalation of diluted sprays especially factory workers involved in synthesizing pesticides.

The present study was conducted to study the adverse effects that might occur in the cardiac muscle of adult albino rats following chlorpyrifos administration, as well as the possible protective effect of ascorbic acid (vitamin C) as an antioxidant, using histological and histochemical methods.

The study was carried out on forty normal adult albino Sprauge­ Dewely rats. Weighing 100-150 grams and with an average age ofthree months. They are divided into four groups.