Efficacy and Tolerability of Sildenafil / L-Arginine Combination Relative to Sildenafil alone in patients with Organic Erectile Dysfunction
Fatma Alzahraa Aziz Mohamed Fouad;
Abstract
Background:
Erectile dysfunction (ED) is the recurrent inability to reach a penile erection hard enough for satisfactory vaginal penetration without interruption of sexual performance. It is a serious problem that is affected by age. The physiological mechanism of erection is a synergy between reflexogenic and psychogenic penile erections that mainly depends on nitric oxide release.
Objectives:
Test the efficacy and safety of adding oral L-Arginine 3 grams daily to oral Sildenafil 50 mg three times weekly compared to oral Sildenafil 50 mg only three times weekly on the treatment of organic non-psychogenic Erectile dysfunction.
Material and methods:
Randomized controlled study of eight weeks duration with two parallel groups of erectile dysfunction (ED). Patients; one group received Sildenafil 50 mg every other day, while the other group received a combination of Sildenafil (every other day) and L-Arginine 3 grams every day. Efficacy was assessed by measuring the clinical penile rigidity and International Index of Erectile function (IIEF-5) score at the baseline and after 8 weeks. Side effects were evaluated across the two groups.
Results:
The mean age was 56.3±5.1 years and 56.2±4.4 years in Sildenafil and combination groups respectively. At baseline the results of both clinical penile rigidity assessment and the score of International Index of Erectile Function (IIEF) show non-significant difference between the two groups; whereas there was statistically significant difference in the grades of ED in the combination group than the Sildenafil group (p value < 0.0001).
At the end of the study evaluation of clinical penile rigidity assessment which shows statistically significant improvement towards the combination group versus the Sildenafil group(p value < 0.0001).There was a trend towards increase International Index of Erectile Function score to the combination group versus the Sildenafil group but does not reach statistical significance (p value 0.05).The grades of erectile dysfunction based on International Index of Erectile Function (IIEF) were statistically significant in the combination group versus the Sildenafil group(p value < 0.0001).Side effects were the same between the two groups except for gastritis which was statistically significant among the combination group versus the Sildenafil group.
Conclusion:
L-Arginine can be used as an additive treatment to Sildenafil for the treatment of erectile dysfunction, with a good safety and acceptable efficacy.
Erectile dysfunction (ED) is the recurrent inability to reach a penile erection hard enough for satisfactory vaginal penetration without interruption of sexual performance. It is a serious problem that is affected by age. The physiological mechanism of erection is a synergy between reflexogenic and psychogenic penile erections that mainly depends on nitric oxide release.
Objectives:
Test the efficacy and safety of adding oral L-Arginine 3 grams daily to oral Sildenafil 50 mg three times weekly compared to oral Sildenafil 50 mg only three times weekly on the treatment of organic non-psychogenic Erectile dysfunction.
Material and methods:
Randomized controlled study of eight weeks duration with two parallel groups of erectile dysfunction (ED). Patients; one group received Sildenafil 50 mg every other day, while the other group received a combination of Sildenafil (every other day) and L-Arginine 3 grams every day. Efficacy was assessed by measuring the clinical penile rigidity and International Index of Erectile function (IIEF-5) score at the baseline and after 8 weeks. Side effects were evaluated across the two groups.
Results:
The mean age was 56.3±5.1 years and 56.2±4.4 years in Sildenafil and combination groups respectively. At baseline the results of both clinical penile rigidity assessment and the score of International Index of Erectile Function (IIEF) show non-significant difference between the two groups; whereas there was statistically significant difference in the grades of ED in the combination group than the Sildenafil group (p value < 0.0001).
At the end of the study evaluation of clinical penile rigidity assessment which shows statistically significant improvement towards the combination group versus the Sildenafil group(p value < 0.0001).There was a trend towards increase International Index of Erectile Function score to the combination group versus the Sildenafil group but does not reach statistical significance (p value 0.05).The grades of erectile dysfunction based on International Index of Erectile Function (IIEF) were statistically significant in the combination group versus the Sildenafil group(p value < 0.0001).Side effects were the same between the two groups except for gastritis which was statistically significant among the combination group versus the Sildenafil group.
Conclusion:
L-Arginine can be used as an additive treatment to Sildenafil for the treatment of erectile dysfunction, with a good safety and acceptable efficacy.
Other data
| Title | Efficacy and Tolerability of Sildenafil / L-Arginine Combination Relative to Sildenafil alone in patients with Organic Erectile Dysfunction | Other Titles | دراسة فاعلية وتحمل السيلدينافيل مندمجا مع الال ارجنين بالمقارنة مع السيلدينافيل منفردا لعلاج اعراض ضعف الانتصاب العضوى عند الرجال | Authors | Fatma Alzahraa Aziz Mohamed Fouad | Issue Date | 2020 |
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