Evaluation of plasma M2-Pyruvate Kinase as a novel biomarker in the differentiation between Functional and Organic Colonic Disorders

Abstract

Differentiating between functional bowel disorders, such as irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD), can often be difficult as they present with similar symptoms. Noninvasive biomarkers in IBD are being increasingly recognized as important, both at the initial diagnosis and for monitoring disease activity. They also play a valuable role in differentiating organic GI disease from functional disorders by examining the entire GI tract. Colorectal cancer (CRC) is a common and lethal disease., CRC is one of the most common malignancies in Egypt. The majority of CRC cases are preventable by early detection in asymptomatic patients at a curable stage as it might develop from variant processes like colorectal polyps and inflammatory bowel disease (IBD). Neoplastic polyps of the colon and rectum, namely tubular and villous adenomas are precursor lesions of colorectal cancer. Nearly 95% of sporadic colorectal cancers develop from these adenomas. Early detection and removal of an adenoma prior to malignant transformation may reduce the risk of colorectal cancer. The gold standard for the early detection of CRC is colonoscopy. The selection of patients who should undergo endoscopic or radiological procedures is one of the key points of the diagnostic process of CRC, which should avoid the abuse of invasive and expensive tests as well as the