Expression of Soluble CD 163 in Pediatric Patient with Chronic Liver Disease

Abstract

: Chronic liver disease is a major problem world wide. Patient with chronic liver disease may develop liver failure due to severe acute exacerbation or due to progressive liver damage. Soluble cluster of differentiation 163 (sCD163) could be easily detected in serum and tissue fluid, which may reflect the activation of mononuclear phagocyte cells. It is reported that CD163 showed anti inflammatory effect in patients with liver failure. Aim of the Work: To investigate the diagnostic values of sCD163 in pediatric patients with chronic liver disease. Patients and Methods: This study was conducted on 35 Pediatric Patients with chronic liver disease They were 19 males and 16 females with male to female ratio of 1.2: 1, their ages ranges from 5 monthes to16 years. Another 20 apparently healthy children, age and sex matched with the disease group were enrolled as a control group. Blood samples were analysed for scd163 using commercial ELISA kits according to the manufacturer’s instruction Results: Our study shows that there was no statistically significant relation found between SCD163 level and gender of the chronic liver disease patients .Our study show that there was highly statistically significant increase in the level of SCD163 in chronic liver disease group than control group with p-value < 0.001. In our study we found that there was statistically significant increase in the level of SCD163 in chronic liver disease group with progression from child classification class A to child classification classC with p-value 0.017. Conclusion: SCD163 can be used for the evaluation of prognosis of chronic liver disease, and the up-regulation of SCD163 closely correlated with the severity of the chronic liver disease.