Assessment of the efficacy of uterine artery Doppler in predicting the response to Mefenamic Acid during treatment of women having IUCD associated menorrhagia

Abstract

Bleeding with IUCDs is considered iatrogenic dysfunctional uterine bleeding. The bleeding associated with IUCD use may either occur during menstruation (heavy and/or prolonged) or in the form of intermenstrual bleeding and spotting. The IUCD increases menstrual bleeding by its impact on several aspects of endometrial hemostasis. Some prostaglandins may cause increase vascularity and vascular permeability and some prostaglandins inhibit platelet activity, the increased production of prostaglandins may contribute to endometrial bleeding synthesis and release could be stimulated in IUCD exposed endometrium. IUCD induced menorrhagia might be correlated with poor contractility of spiral arterioles in spontaneous layer of the endometrium. Also the increased fibrinolysis with IUCD is likely to arise as a result of damage to the capillary plexus causing increased and prolonged menstrual bleeding. According to close linkage of raised vascularity issues in those category of cases uterine artery Doppler indices (RI), (PI) are broadly investigated by various research groups particularly in response to hemostatic medications implemented to reduce menstrual blood loss to reveal and observe the uterine hemodynamic changes in cases with IUCD induced bleeding and response levels to used