Corneal Densitometry Changes after Epithelium-Off Corneal Collagen Crosslinking

Abstract

eratoconus is a progressive non-inflammatory, degenerative disease that affects the integrity of the collagen matrix within the corneal stroma. Its hallmark is the formation of a localized cone-shaped ectasia, and accompanied by thinning of the stroma in the area of the cone. This might cause irregular astigmatism and a steep corneal curvature. Due to the great variability among patients with keratoconus, it is vital to grade this disease to provide some general guidance for the clinician regarding the level of progression and the treatment options that can be offered. Various classifications are depending on which principal factors are considered. Traditionally, the most widely used classification is the Amsler-Krumeich (1946) scale. This scale is based primarily on keratometric criteria but also includes other factors, such as refraction and pachymetry. Until the last decade of the 20th century, the only surgical option for patients with keratoconus was keratoplasty procedures. However, nowadays there are numerous procedures that tend to stop the progression of the disease and improve the patient's visual function, which includes corneal collagen crosslinking, Intra-corneal stromal implants and different modalities of keratoplasty