(EFFECT OF " ACRYLAMIDE" ON THE NEUROMUSCULAR JUNCTIONS OF ALBINO SWISS MICE AND THE ROLE OF VITAMIN. "A"(A-VITON

Abstract

The present investigation was undertaken to detertnine whether accumulated acrylamide doses in healthy albino Swiss mice might affect the function of myoneural junctions as well as skeletal muscle, by producing morphological and histological changes in the different components, or not. To the best of our knowledge, this is the first detailed light and ultrastructural study that showed a spectrum of neuromuscular alterations due to ACR and/or A-Viton treatment. [n order to detertnine the relationship between the dose of ACR

administration and its toxicity, two dose levels were used.

We were also interested in determining the role of vitamin A (A-Viton) on inhibiting or promoting the toxic effect produced by ACR. Experimental mice were treated with either ACR or A-Viton or both according to a planned dose-time schedule. Our study included light and ultrastructural detailed descriptions of mouse skeletal muscle and related motor endplates in all experimental group as well as their control. The ANOVA test was used for statistical analysis of some parameters.

Results obtained during this investigation are summarized as follows:

1. It was found that ACR chemical induced dose dependent changes judged from the observation that: