ERYTHROCYTE SUPEROXIDE DISMUTASE AND PLASMA MALONDIALDEHYDE LEVELS IN CHILDREN WITH COLLAGEN DISEASES

Abstract

This study was done in Assiut University Hospital in the period from January 2000 to June 200 I and included 27 patients were attending the pediatric and rheumatology and rehabilitation clinics. The 27 patients were divided into 3 groups; group I consisted of I 8 JRA patients, before treatment with Asprin {Group lA) and after treatment with Asprin (Group !B); group II consisted of 9 SLE patients, before treatment with Asprin (Group IIA) and after treatment with Asprin{Group liB) and group III consisted of I 0 healthy individuals of matchable age and sex (control group).

Of the studied patients, the age of group I ranged from 7 to 13 years with a mean of9.5 ± 1.85 years (4 males and 14 females), while the age of group II ranged from 9 to 14 years with a mean of 11.22 ± 1.66 years (3 males and 6 females).

The aim of this study was to detect the role of oxidant stress in the pathogenesis of JRA and SLE and the possibility of addition of antioxidants in the regimens of their treatment. Beside full history and clinical examination, all studied children (patients and controls) were subjected to the following investigations: complete blood count, ESR, CRP, urine analysis, stool analysis, prothrombin time and concentration, partial thromboplastin time, liver function tests, serum urea and creatinine, abdominal ultrasonography, serum malondialdehyde (MDA) and erythrocyte superoxide dismutase (SOD).